Publication:
ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer

Simple item page
dc.contributor.authorRosas, G
dc.contributor.authorRuiz, Rossana
dc.contributor.authorAraujo, JM
dc.contributor.authorPinto, JA
dc.contributor.authorMas L, Luis
dc.date.accessioned2024-07-01T16:28:55Z
dc.date.available2024-07-01T16:28:55Z
dc.date.issued2019
dc.description.abstractThe ALK receptor tyrosine kinase (ALK) gene encodes a transmembrane protein rearranged in 2-7% of non-small cell lung cancer (NSCLC) cases. This gene has become the second most studied therapeutic target after EGFR due to the implied therapeutic opportunities. While the diagnostic of ALK rearrangements is well established, small molecules targeting ALK are in constant evolution because tumor cells eventually will develop mechanisms of resistance. In this review we describe the biology of the ALK gene, alterations, epidemiology, diagnostic tests as well as strategies of treatment.
dc.formatapplication/pdf
dc.identifier.doihttps: //doi.org/10.1016/j.critrevonc.2019.02.006
dc.identifier.journalCrit Rev Oncol Hematol
dc.identifier.urihttps://hdl.handle.net/20.500.14703/131
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.publisher.countryIE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectALK
dc.subjectDiagnostic tests
dc.subjectNon-small cell lung cancer
dc.subjectTyrosine-kinase inhibitors
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.02.21
dc.titleALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
G Rosas 2019.pdf
Size:
314.46 KB
Format:
Adobe Portable Document Format
Download

Collections

Artículos originales