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Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies

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dc.contributor.advisorJorge Luis
dc.contributor.authorCastañeda, Carlos A.
dc.contributor.authorCastillo, Miluska
dc.contributor.authorAliaga, Karina
dc.contributor.authorBernabé, Luis A.
dc.contributor.authorCasavilca, Sandro
dc.contributor.authorSánchez, Joselyn
dc.contributor.authorTorres-Cabala, Carlos A.
dc.contributor.authorGómez , Henry L.
dc.contributor.authorMas, Luis
dc.contributor.authorDunstan, Jorge
dc.contributor.authorCotrina, José M
dc.contributor.authorAbugattas, Julio
dc.contributor.authorChávez, Iván
dc.contributor.authorRuiz, Eloy
dc.contributor.authorMontenegro, Paola
dc.contributor.authorRojas, Víctor
dc.contributor.authorOrrego, Enrique
dc.contributor.authorGálvez-Nino, Marco
dc.contributor.authorFélix , Brayam
dc.contributor.authorLanda-Baella, María P.
dc.contributor.authorVidaurre, Tatiana
dc.contributor.authorVilla, María R
dc.contributor.authorZevallos, Rocío
dc.contributor.authorTaxa, Luis
dc.contributor.authorGuerra, Henry
dc.date.accessioned2026-02-17T15:53:31Z
dc.date.available2026-02-17T15:53:31Z
dc.date.issued2019
dc.description.abstractAim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. Methods: 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3+, CD4+, CD8+, CD20+, CD68+ and CD163+ cells by digital analysis. Results: TIL levels were higher in invasive margin compartments (IMC). TIL in IMC, intratumoral and stromal compartments predicted survival. CC and gastric cancer had higher TIL in intratumoral; CC and CM had higher TIL in stromal compartment and IMC. CM had the highest density of lymphocyte and macrophage populations. CD20 density was associated with survival in the whole series. Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies.
dc.description.sponsorshipFunding text 1: This work was partly supported by the Programa Nacional de Innovacion para la Competitividad y Productividad-Innovate Peru (contract no. 317-PNICP-EC-2014), and CONCYTEC (contract no. 197-2015-FONDECYT). The authors have no other relevant||Funding text 2: This work was partly supported by the Programa Nacional de Innovacion para la Competitividad y Productividad-Innovate Peru (contract no. 317-PNICP-EC-2014), and CONCYTEC (contract no. 197-2015-FONDECYT). The authors have no other relevant affiliations or financialinvolvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
dc.formatapplication/pdf
dc.identifier.doi10.2217/bmm-2019-0178
dc.identifier.journalNational Library of Medicine
dc.identifier.urihttps://hdl.handle.net/20.500.14703/503
dc.language.isoeng
dc.publisherPublmed
dc.publisher.countryPE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiomarker
dc.subjectCancer
dc.subjectCervix
dc.subjectDensity
dc.subjectGastric
dc.subjectGlioblastoma
dc.subjectLung
dc.subjectLymphocytes
dc.subjectMacrophages
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.02.21
dc.titleLevel of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

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