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Distribution of tumor-infiltrating immune cells in glioblastoma

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dc.contributor.authorOrrego Puelles, Enrique,
dc.contributor.authorCastaneda, Carlos A
dc.contributor.authorCastillo, Miluska
dc.contributor.authorBernabe, LA
dc.contributor.authorCasavilca, Sandro
dc.contributor.authorChakravarti, A
dc.contributor.authorMeng, W
dc.contributor.authorGarcia-Corrochano, Pamela
dc.contributor.authorVilla-Robles, MR
dc.contributor.authorZevallos, R
dc.contributor.authorMejia, O
dc.contributor.authorDeza, Pedro
dc.contributor.authorBelmar-Lopez
dc.contributor.authorOjeda, CL
dc.date.accessioned2024-07-01T16:29:07Z
dc.date.available2024-07-01T16:29:07Z
dc.date.issued2018
dc.description.abstractAim: Evaluation of features related to infiltrating immune cell level in glioblastoma. Methods: Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis. Results: CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest density. Higher CD4+ was associated with unmethylated MGMT (p = 0.016). Higher CD8+ was associated with larger tumoral size (p = 0.027). Higher CD163+ was associated with higher age (p = 0.044) and recursive partitioning analysis = 4. Women (p < 0.05), total resection (p < 0.05), MGMT-methylation (p < 0.001), radiotherapy (p < 0.001), chemotherapy (p < 0.001) and lower CD4+ (p < 0.05) were associated with longer overall survival. Conclusion: Macrophages are more frequent than TILs. Some subsets are associated with clinical features.
dc.formatapplication/pdf
dc.identifier.doi10.2217/cns-2017-0037
dc.identifier.journalCNS Oncol
dc.identifier.urihttps://hdl.handle.net/20.500.14703/148
dc.language.isoeng
dc.publisherFuture Medicine Ltd.
dc.publisher.countryUK
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMGMT
dc.subjectbiomarker
dc.subjectglioblastoma
dc.subjectmacrophages
dc.subjectoverall survival
dc.subjectprognosis
dc.subjecttumor-infiltrating lymphocytes
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.02.21
dc.titleDistribution of tumor-infiltrating immune cells in glioblastoma
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

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