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Browsing Artículos by Subject "21-Gene Expression Assay"

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    Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
    (Massachussetts Medical Society, 2015) Sparano, JA; Gray, RJ; Makower, DF; Pritchard, KI; Albain, KS; Hayes, DF; Geyer, CE Jr; Dees, EC; Perez, EA; Olson, JA Jr; Zujewski, J; Lively, T; Badve, SS; Saphner, TJ; Wagner, LI; Whelan, TJ; Ellis, MJ; Paik, S; Wood, WC; Ravdin, P; Keane, MM; Gomez, HL; Reddy, PS; Goggins, TF; Mayer, IA; Brufsky, AM; Toppmeyer, DL; Kaklamani, VG; Atkins, JN; Berenberg, JL; Sledge, GW
    Prior studies with the use of a prospective–retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.