Browsing by Author "Ruiz-Mendoza, R"

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Genomic landscape of lung cancer in the young
(Frontiers Media S.A., 2022) Ruiz-Mendoza, R; Galvez-Nino, M; Roque, K; Montes-gila, J; Nuñez, Mará; Raez, Luis; Sánchez-Gambetta, Sergio; Jaúregui, Sandra; Viale, Sandra; Smith, Edward S; Pinto, JA; Mas López, L
Background: Lung cancer in the young is a rare entity of great interest due to the high frequency of targetable mutations. In this study, we explored the genomic landscape of non-small cell lung cancer (NSCLC) in young patients and compared it with genetic alterations in older patients. Methods: Comparative study of the genomic profile of NSCLC young (≤40 years old) vs older patients (>40 years old) from Instituto Nacional de Enfermedades Neoplásicas (INEN) in Lima, Peru. Archival paraffin-embedded tumor samples were profiled with FoundationOne CDx assay to identify short variants alterations (insertions and deletions), copy number variations (CNV), tumor mutational burden and microsatellite instability in 324 driver genes and rearrangements in 28 commonly rearranged genes. A targetable alteration was defined as any alteration in a driver oncogene for which an FDA approved therapy existed at the time of study enrollment. Results: Overall, 62 tumors were profiled, 32 from young and 30 from older patients. All clinicopathological features (smoking status, clinical stage, and histology) were similar between groups, except for gender (65.6% of females in the younger group vs 40% in the older group, P=0.043). At least one actionable mutation was present in 84.4% and 83.3% in younger and older patients, respectively. Alteration rates in the main genes were: BRAF, 3.1%(n=1) vs 0% EGFR, 46.9% (n=15) vs 43.3% (n=13) ERBB2, 12.5% (n=4) vs 16.7% (n=5) KRAS, 15.6% (n=5) vs 16.7% (n=5) ALK, 6.3% (n=2) vs 3.3% (n=1) RET, 0.0% vs 3.3% (n=1) RET, 0.0% vs 3.3% (n=1) ROS1, 3.1% (n=1) vs 3.3% (n=1) NTRK1, 0.0% vs 3.3% (n=1) and MET, 3.1% (n=1) vs 13.3% (n=4). Mean TMB was 4.04 Mut/Mb (SD ± 3.98) for young vs 8.06 Mut/Mb (SD ± 9.84) for older patients (P=0.016). There were not significant differences in CNV, frequency of gene rearrangements, or microsatellites instability. Conclusion: NSCLC in the young in our cohort was characterized by a high frequency of actionable genetic aberrations and a low TMB, which was also true for our older patients. The enrichment of actionable mutations in young patients described in other reports might be attributed to differences in the etiology and clinicopathological characteristics between younger and older patients and therefore not be applicable to all populations.
The impact of telemedicine on cancer care: real-world experience from a Peruvian institute during the COVID-19 pandemic
(Newlands Press Ltd, 2022) Roque, K; Ruiz-Mendoza, R; Otoya-Fernandez, I; Galarreta-Zegarra, J; Vidaurre Rojas, T; Andrade-De Mello, R; Neciosup-Delgado, S; Mas-López, L; Gómez Moreno, HL
Background: The COVID-19 pandemic caused discontinuities in cancer care (CC) in most countries. Here, the authors describe the real-world impacts of implementing a contingency plan employing telemedicine for CC. Methods: A retrospective study of patients who received CC through telemedicine at the Instituto Nacional de Enfermedades Neoplasicas, Peru, from March 2020 to February 2021 was conducted. Impacts were measured by comparing the amount of CC administered during the pandemic versus the prior year. Results: A total of 16,456 telemedicine visits were carried out. An annual comparative analysis showed a gap of 23% and telemedicine accounted for 27.6% of the total CC administered during the pandemic. A high (4.50/5) level of patient satisfaction with telemedicine was reported. Conclusion: Telemedicine is an important tool to facilitate the continuity of CC.