Browsing by Author "Rashid, R"

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Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
(Association for Research in Vision and Ophthalmology Inc., 2024) Hicks, RM; Ji, X; Zou, Y; Sultana, S; Rashid, R; Sherief, ST; Cassoux, N; Garcia, Leon, JL; Diaz, Coronado, RY; López, AMZ; Ushakova, TL; Polyakov, VG; Roy, SR; Ahmad, A; Reddy, MA; Sagoo, MS; Harby, LA; Berry, JL; Polski, A; Astbury, NJ; Bascaran, C; Blum, S; Bowman, R; Burton, MJ; Gomel, N; Keren-Froim, N; Madgar, S; Zondervan, M; Kaliki, S; Fabian, ID; Stacey, AW
PURPOSE. Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb. METHODS. A multinational, longitudinal cohort study was conducted with patients from 11 centers in 10 countries who presented with treatment naïve Rb from January to December 2019. Variables of interest included age, sex, and size characteristics at birth and at time of presentation, as well as germline mutation status. After Bonferroni correction, results were statistically significant if the P value was less than 0.005. RESULTS. We enrolled 696 patients, with 253 analyzed after exclusion criteria applied. Between somatic (n = 39) and heritable (n = 214) Rb cohorts, with males and females analyzed separately, there was no significant difference in birth weight percentile, weight percentile at time of diagnosis, length percentile at time of diagnosis, weight-for-length percentile at time of diagnosis, or change of weight percentile from birth to time of diagnosis. Patients with heritable Rb had a smaller mean weight percentile at birth and smaller mean weight and length percentiles at time of diagnosis with Rb, although this difference was not statistically significant. All cohorts experienced a slight negative change of weight percentile from birth to time of diagnosis. No cohort mean percentiles met criteria for failure to thrive, defined as less than the 5th percentile. CONCLUSIONS. Children with Rb seem to have normal birth and childhood growth patterns. There is no definitive evidence that somatic or heritable Rb has a biological or environmental impact on childhood growth parameters. © 2024 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.
Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries
(BMJ Publishing Group, 2023) Nishath, T; Li, X; Chandramohan, A; Othus, M; Ji, X; Zou, Y; Sultana, S; Rashid, R; Sherief, ST; Cassoux, N; Leon, JLG; Coronado, RD; Lopez, AMZ; Ushakova, TL; Polyakov, VG; Roy, SR; Ahmad, A; Reddy, A; Sagoo, MS; Harby, LA; Kim, JW; Berry, JL; Polski, A; Astbury, N; Bascaran, C; Blum, S; Bowman, R; Burton, MJ; Foster, A; Gomel, N; Keren-Froim, N; Madgar, S; Zondervan, M; Kaliki, S; Fabian, ID; Stacey, A
Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients. Methods A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment. Results Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206). Conclusion Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country. © Author(s) (or their employer(s)) 2023.
The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study
(Springer Nature, 2023) Lloyd, P; Westcott, M; Kaliki, S; Ji, X; Zou, Y; Rashid, R; Sultana, S; Sherief, ST; Cassoux, N; Diaz-Coronado, RY; Garcia-Leon, JL; Lopez, AMZ; Polyakov, VG; Ushakova, TL; Roy, SR; Ahmad, A; Harby, LA; Berry, JL; Kim, J; Polski, A; Astbury, NJ; Bascaran, C; Blum, S; Bowman, R; Burton, MJ; Foster, A; Gomel, N; Keren-Froim, N; Madgar, S; Stacey, AW; Mohamed, A; Zondervan, M; Sagoo, MS; Fabian, ID; Reddy, MA
Background/Objectives: Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from a de novo germline pathogenic variant in the RB1 gene. Both advanced maternal age and decreasing birth order are known to increase the risk of de novo germline pathogenic variants, while the influence of national wealth is understudied. This cohort study aimed to retrospectively observe whether these factors influence the ratio of bilateral retinoblastoma cases compared to unilateral retinoblastoma, thereby inferring an influence on the development of de novo germline pathogenic variants in RB1. Subjects/Methods: Data from 688 patients from 11 centres in 10 countries were analysed using a series of statistical methods. Results: No associations were found between advanced maternal age, birth order or GDP per capita and the ratio of bilateral to unilateral retinoblastoma cases (p values = 0.534, 0.201, 0.067, respectively), indicating that these factors do not contribute to the development of a de novo pathogenic variant. Conclusions: Despite a lack of a definitive control group and genetic testing, this study demonstrates that advanced maternal age, birth order or GDP per capita do not influence the risk of developing a bilateral retinoblastoma.