Browsing by Author "Luna-Abanto, J"

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Cancer incidence and mortality trends in young adults in Metropolitan Lima young adults, 1990-2012
(Cancer Intellilgence, 2020) Luna-Abanto, J; Ruiz, LG; Laura-Martinez, J; Tairo-Cerron, T
Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis.Design, setting, and participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main outcomes and measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis.Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs.
Disección radical de axila por carcinoma de ovario metastásico
(Elsevier Doyma, 2022) García-Ruiz, L; Zapata-Ojeda, E; Luna-Abanto, J; García, L; Córdova, M; Montoya, A
Metastatic ovarian carcinoma involving axillary nodes is a rare condition that guides us to rule out breast cancer. We report the case of a patient with this entity who underwent surgical treatment and was subsequently referred for complementary treatment. © 2020 SESPM
Factores de riesgo asociados con morbilidad y mortalidad postoperatoria en gastrectomía radical D2 por cáncer gástrico
(Asociacion Mexicana de Gastroenterologia, 2022) Paredes-Torres, OR; García-Ruiz, L; Luna-Abanto, J; Meza-García, K; Chávez-Passiuri, IK; Berrospi-Espinoza, F; Luque-Vásquez Vásquez, C; Ruiz-Figueroa, E; Payet-Meza, E
Introduction and aims: Surgery is the main treatment for gastric cancer. D2 radical gastrectomy is associated with a variable postoperative morbidity and mortality rate worldwide. The aim of the present study was to identify the risk factors associated with the postoperative morbidity and mortality of D2 radical gastrectomy, with curative intent, for gastric cancer. Materials and methods: A retrospective case series was conducted, in which the medical records were reviewed of patients with gastric cancer that underwent D2 radical gastrectomy, within the time frame of January 2014 and December 2018. Univariate and multivariate analyses were carried out to identify the risk factors related to postoperative morbidity and mortality within 90 days. Results: The percentages of postoperative morbidity and mortality in 691 patients were 23.3% and 3.3%, respectively. In the multivariate analysis, age ≥ 70 years (OR = 1.85, 95% CI: 1.25-2.76), ASA III-IV (OR = 2.06, 95% CI: 1.28-3.34), total gastrectomy (OR = 1.96, 95% CI:1.19-3.23), and pancreatosplenectomy (OR = 5.41, 95% CI: 1.42-20.61) were associated with greater postoperative morbidity, and age ≥ 70 years (OR = 4.92, 95% CI:1.78-13.65), lower BMI (OR = 0.81, 95% CI: 0.71-0.92), and hypoalbuminemia (OR = 0.91, 95% CI: 0.85-0.98) were associated with greater mortality in distal and total D2 radical gastrectomy. Conclusions: D2 radical gastrectomy for gastric cancer was shown to be a safe treatment, with low postoperative morbidity and mortality rates. Age ≥ 70 years, ASA III-IV, total gastrectomy, and pancreatosplenectomy were factors associated with a higher complication rate. Age ≥ 70 years, lower BMI, and hypoalbuminemia were mortality predictors in distal and total radical gastrectomy. © 2021 Asociación Mexicana de Gastroenterología
Gastric myeloid sarcoma: A case report
(Baishideng Publishing Group, 2021) Rioja, P; Macetas, J; Luna-Abanto, J; Tirado-Hurtado, I; Enriquez, DJ
Background: Myeloid sarcoma (MS) is a rare hematologic malignancy defined as an extramedullary tumor of immature granulocytic cells. It can occur as primary or de novo and be associated with myelodysplasia or myeloproliferative neoplasms. The most frequent locations are the skin, lymph nodes and bones. The case of a patient with a diagnosis of primary granulocytic de novo gastric MS is reported. Case summary: A 19-year-old female patient with MS, whose abdominal computed tomography showed a bulky tumor of 16.5 cm in the gastric chamber with infiltration in the retroperitoneal, pancreatic and bile duct region; the histological study showed gastric mucosa diffusely infiltrated by mononucleated cells and the immunohistochemistry expressed myeloperoxidase. After receiving induction chemotherapy based on the 3 + 7 regimen (daunorubicin/cytarabine), the patient developed severe hematological toxicity and neutropenic typhlitis which required a prolonged medical treatment. She presented a rapid disease progression. Although she received supportive treatment, the patient died. Conclusion: Gastric primary de novo MS is a rare and aggressive course neoplasm, fostering knowledge is very important to decide its management and to promote more approaches focused on understanding this pathology and its particularities in our population.
Impact of cancer awareness campaigns in Peru: a 5-year Google Trends analysis
(ecancer Global Foundation, 2022) Luna-Abanto, J; Gamarra, L; Desposoro Armestar, D; Huamanchau Condori, B; Mendoza Tisoc, GB; Flores-Trujillo, G; Apumayta, E; Tairo-Cerrón, T; Centurión-Rodríguez, C; García-Ruiz, L; Espinoza-Figueroa, J; Meza-Garcia, KT; Navarro-Yovera, J; Ubillus-Trujillo, M; Sarria-Bardales, G
Background: The aim of this research was to characterise the interest on the most frequent cancers in Peru through Google Trends, its geographic and temporal relationship with massive awareness campaigns. Methods: A temporal trends analysis for the last 5 years was carried out, comparing the Relative Search Volume (RSV) with the dates of mass cancer awareness campaigns in Peru. Google Trends application was used to evaluate the interest in the topics: breast, prostate, cervical stomach and colorectal cancer between 1 January 2016 and 31 December 2020, expressed in RSV. The annual RSV for each neoplasm was compared, as well as its annual variation using the Kruskal-Wallis test. The correlation between the RSV and the estimated incidence for each province was measured using the Spearman test. Results: The topics with the highest RSV were breast (median: 20, range: 6-100) and prostate cancer (median: 28, range: 9-48). The topic 'breast cancer' showed a cyclical punctual increase in October, its awareness month. Searches for cervical, stomach and colorectal cancer were smaller and did not show peaks of interest. It was observed that the RSV was variable when compared with previous years (p < 0.05 for all the evaluated topics). Geographically, different provincial configurations of interest were observed according to neoplasia. When correlating the RSV with the incidence by province, a non-significant positive correlation (p > 0.05) was found for breast, cervical and colorectal cancer. Conclusions: This study suggests a positive temporal correlation between RSV and awareness cancer campaigns in Peru specially to breast cancer and, to a lesser extent, prostate cancer. Significant variations of interest were demonstrated for each neoplasm among the evaluated years. No significant correlation was found between the incidence rate and the average RSV among Peruvian provinces.
Lytic bone lesion as the first manifestation of late recurrence of gastric cancer
(ARAN Ediciones S.L, 2023) Garcia, KTM; Cucho, SLP; Luna-Abanto, J
The incidence of gastric cancer has declined worldwide, it is the second most common cancer worldwide and two thirds of these occurs in developing countries. In Peru, this neoplasm, has one of the highest incidence and mortality rates. The main sites of gastric adenocarcinoma metastasis are the liver and lung; In contrast, bone metastasis are an uncommon finding up to 0.9 to 2% of patients and is associated with an ominous prognosis. We present the case of a 48-year-old female patient diagnosed with gastric cancer treated surgically and with regular controls. 5 years later, she was admitted due to pain in the left knee and increased volume. Knee radiographs reported a lytic lesion in the medial condyle and distal diaphysis of the left femur, with soft tissue involvement, wide transition zone, cortical rupture. Bone scintigraphy described bone oligo metastatic disease. Extension studies were negative for visceral metastasis. Palliative biopsy and curettage of the femur lesion was performed; the pathology was consistent with gastric adenocarcinoma metastasis.
The need to focus on long-term outcomes after transanal total mesorectal excision for rectal cancer
(John Wiley and Sons Inc, 2022) Angulo-Cruzado, MA; Luna-Abanto, J
The data that support the findings of this study are available from the corresponding author upon reasonable request.