Browsing by Author "Ferreira, J"

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    Improved Risk Prediction in Human Papillomavirus-Associated Endocervical Adenocarcinoma Through Assessment of Binary Silva Pattern-based Classification: An International Multicenter Retrospective Observational Study Led by the International Society of Gynecological Pathologists (ISGyP)
    (Lippincott Williams and Wilkins, 2024) Powell, A; Hodgson, A; Cohen, PA; Rabban, TJ; Park, KJ; McCluggage, WG; Gilks, CB; Singh, N; Oliva, E; Cardinal, LH; Díaz, LB; Falcón, F; Garcia, Kamermann, FA; Sciaccaluga, MD; Bittinger, S; Bulsara, M; Codde, J; Newman, MR; Spinderjeet, S; Talia, KL; Volchek, M; Djordevic, B; Hoang, L; Parra-Herran, C; Turashvili, G; Gao, H-W; Jiang, Q; Li, J; Liu, A; Sun, P-L; Wang, Y; Zhang, J; Bazalová, B; Bouda, J; Dundr, P; Ondic, O; Gotthardt, N; Hoehn, AK; Horn, L-C; Akakpo, KP; Ayabilah, EA; Yarney, J; Tse, K-Y; Wong, RW; Wong, TS; Ip, PPC; Rai, B; Srinivasan, R; Conlon, N; Ardighieri, L; Bignotti, E; Ferrari, F; Mandato, VD; Mastrofilippo, V; Odicino, F; Palicelli, A; Pesci, A; Zanelli, M; Zannoni, GF; Kiyokawa, T; Alvarado-Cabrero, I; Esperanza, M; Webb, P; Bartosch, C; Felix, A; Ferreira, J; Lérias, S; SoutoMoura, M; Kim, K-R; Akkour, KM; Aljehani, AM; Arafah, MA; Tulbah, AM; Wadee, R; Guarch, R; Guerra, E; Hardisson, D; Matias-Guiu, X; Palacios, J; Pérez-Mies, B; Rakislova, N; Saco, MA; Mateoiu, C; Bleeker, MCG; Mom, CH; Ozdemir, DA; Salman, C; Usubütün, A; Abu-Sinn, D; Arif, S; Attygalle, A; Bhatnagar, A; Biddlestone, LR; Culora, G; Haider, S; Ibrahim, S; Johnson, S; Kaushik, S; Khan, R; Leen, SLS; Latimer, A; Mandalia, T; Milan, D; Mukonoweshuro, P; Syed, S; Vergine, M; Vroobels, K; Wise, O; Wong, J; Hui, P; JoehlinPrice, AS; Adamson, K; Balzer, B; Banet, N; Bennett, JA; Brainard, J; Buza, N; Fadare, O; Gupta, M; Isacson, C; Kehr, E; Kong, C; Leonard, WA; Lieberman, R; Longacre, TA; Masand, RP; McGregor, SM; Medeiros, F; Miller, M; Moisini, I; Ordulu, Z; Paczos, T; Parkash, V; Pinto, A; Nicolas, MP; Quddus, MR; Riopel, MA; Rivera-Colon, G; Roma, AA; Safdar, NS; Segura, S; Shukla, P; Summey, RM; Tafe, LJ; Varghese, S; Williams-Brown, MY; Wolsky, RJ; Wong, S; Yemelyanova, A; Zhang, G; Zheng, W
    Endocervical adenocarcinomas (EACs) are a group of malignant neoplasms associated with diverse pathogenesis, morphology, and clinical behavior. As a component of the International Society of Gynecological Pathologists International Endocervical Adenocarcinoma Project, a large international retrospective cohort of EACs was generated in an effort to study potential clinicopathological features with prognostic significance that may guide treatment in these patients. In this study, we endeavored to develop a robust human papillomavirus (HPV)-associated EAC prognostic model for surgically treated International Federation of Gynecology and Obstetrics (FIGO) stage IA2 to IB3 adenocarcinomas incorporating patient age, lymphovascular space invasion (LVSI) status, FIGO stage, and pattern of invasion according to the Silva system (traditionally a 3-tier system). Recently, a 2-tier/binary Silva pattern of invasion system has been proposed whereby adenocarcinomas are classified into low-risk (pattern A/pattern B without LVSI) and high-risk (pattern B with LVSI/pattern C) categories. Our cohort comprised 792 patients with HPV-associated EAC. Multivariate analysis showed that a binary Silva pattern of invasion classification was associated with recurrence-free and disease-specific survival (P < 0.05) whereas FIGO 2018 stage I substages were not. Evaluation of the current 3-tiered system showed that disease-specific survival for those patients with pattern B tumors did not significantly differ from that for those patients with pattern C tumors, in contrast to that for those patients with pattern A tumors. These findings underscore the need for prospective studies to further investigate the prognostic significance of stage I HPV-associated EAC substaging and the inclusion of the binary Silva pattern of invasion classification (which includes LVSI status) as a component of treatment recommendations. Copyright © 2024 by the International Society of Gynecological Pathologists.
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    The Latin-American Experience in POEMS Syndrome: A Study of the GELAMM (Grupo de Estudio Latinoamericano de Mieloma Múltiple)
    (S. Karger AG, 2024) Gallardo-Pérez, MM; Negrete-Rodríguez, P; Gertz, MA; Peña, C; Riva, E; Gilli, V; Rodríguez, G; Samánez, C; Ferreira, J; Portiño, S; Montaña, J; León, P; Gutiérrez, Y; Del-Castanhel, C; Seehaus, C; Funes, ME; Meneces-Bustillo, R; Duarte, P; Shanley, C; Elvira, G; Ochoa, P; López-Vidal, H; Martinez-Cordero, H; Vasquez, J; Von-Glasenapp, A; Donoso, J; Viñuela, JL; Ruiz-Delgado, GJ; Ruiz-Argüelles, GJ
    Introduction: POEMS syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The acronym refers to the following features: polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal paraproteinemia, and skin changes. Methods: The study was conducted at 24 hematological centers across 8 Latin-American countries. The study included a total of 46 patients {median age was 52 years (interquartile range [IQR]: 42 61.5), 30 males and 16 females} fulfilling the POEMS syndrome criteria diagnosed over a period of 12 years (January 1, 2011, through July 31, 2023). Epidemiological and clinical data were collected in an ad hoc database sent to the members of GELAMM, as well as the Kolmogorov-Smirnov test and Kaplan-Meier estimates. Results: All patients had polyneuropathy and monoclonal gammopathy; 89% had bone marrow plasma cell infiltration, 33% had sclerotic bone lesions. Only 10 patients underwent vascular endothelial growth factor (VEGF) testing in plasma samples. The paraproteinemia was IgG λ in 32% and IgA λ in 30%. 59% patients presented with cutaneous changes, mainly hyperpigmentation, 54% had organomegaly, and 74% endocrinopathy. The median interval from symptom onset to diagnosis was 7.7 months (IQR: 4.0 12.6). 69% of patients received a single line of treatment. The median follow-up period was 25 months (IQR: 9.37 52.0) and the 2-year overall survival rate was 100%. All patients who underwent transplantation (43%) are alive, with a median follow-up of 45.62 months (IQR: 15.46 70). Conclusion: This study investigates POEMS syndrome in Latin America and presents an initial overview of the disease in the region. VEGF usage is recommended for accurate diagnosis, but only 7 hematology centers in the region used it. Survival rate in Latin America is comparable with those observed internationally.