Browsing by Author "Dundr, P"

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    Improved Risk Prediction in Human Papillomavirus-Associated Endocervical Adenocarcinoma Through Assessment of Binary Silva Pattern-based Classification: An International Multicenter Retrospective Observational Study Led by the International Society of Gynecological Pathologists (ISGyP)
    (Lippincott Williams and Wilkins, 2024) Powell, A; Hodgson, A; Cohen, PA; Rabban, TJ; Park, KJ; McCluggage, WG; Gilks, CB; Singh, N; Oliva, E; Cardinal, LH; Díaz, LB; Falcón, F; Garcia, Kamermann, FA; Sciaccaluga, MD; Bittinger, S; Bulsara, M; Codde, J; Newman, MR; Spinderjeet, S; Talia, KL; Volchek, M; Djordevic, B; Hoang, L; Parra-Herran, C; Turashvili, G; Gao, H-W; Jiang, Q; Li, J; Liu, A; Sun, P-L; Wang, Y; Zhang, J; Bazalová, B; Bouda, J; Dundr, P; Ondic, O; Gotthardt, N; Hoehn, AK; Horn, L-C; Akakpo, KP; Ayabilah, EA; Yarney, J; Tse, K-Y; Wong, RW; Wong, TS; Ip, PPC; Rai, B; Srinivasan, R; Conlon, N; Ardighieri, L; Bignotti, E; Ferrari, F; Mandato, VD; Mastrofilippo, V; Odicino, F; Palicelli, A; Pesci, A; Zanelli, M; Zannoni, GF; Kiyokawa, T; Alvarado-Cabrero, I; Esperanza, M; Webb, P; Bartosch, C; Felix, A; Ferreira, J; Lérias, S; SoutoMoura, M; Kim, K-R; Akkour, KM; Aljehani, AM; Arafah, MA; Tulbah, AM; Wadee, R; Guarch, R; Guerra, E; Hardisson, D; Matias-Guiu, X; Palacios, J; Pérez-Mies, B; Rakislova, N; Saco, MA; Mateoiu, C; Bleeker, MCG; Mom, CH; Ozdemir, DA; Salman, C; Usubütün, A; Abu-Sinn, D; Arif, S; Attygalle, A; Bhatnagar, A; Biddlestone, LR; Culora, G; Haider, S; Ibrahim, S; Johnson, S; Kaushik, S; Khan, R; Leen, SLS; Latimer, A; Mandalia, T; Milan, D; Mukonoweshuro, P; Syed, S; Vergine, M; Vroobels, K; Wise, O; Wong, J; Hui, P; JoehlinPrice, AS; Adamson, K; Balzer, B; Banet, N; Bennett, JA; Brainard, J; Buza, N; Fadare, O; Gupta, M; Isacson, C; Kehr, E; Kong, C; Leonard, WA; Lieberman, R; Longacre, TA; Masand, RP; McGregor, SM; Medeiros, F; Miller, M; Moisini, I; Ordulu, Z; Paczos, T; Parkash, V; Pinto, A; Nicolas, MP; Quddus, MR; Riopel, MA; Rivera-Colon, G; Roma, AA; Safdar, NS; Segura, S; Shukla, P; Summey, RM; Tafe, LJ; Varghese, S; Williams-Brown, MY; Wolsky, RJ; Wong, S; Yemelyanova, A; Zhang, G; Zheng, W
    Endocervical adenocarcinomas (EACs) are a group of malignant neoplasms associated with diverse pathogenesis, morphology, and clinical behavior. As a component of the International Society of Gynecological Pathologists International Endocervical Adenocarcinoma Project, a large international retrospective cohort of EACs was generated in an effort to study potential clinicopathological features with prognostic significance that may guide treatment in these patients. In this study, we endeavored to develop a robust human papillomavirus (HPV)-associated EAC prognostic model for surgically treated International Federation of Gynecology and Obstetrics (FIGO) stage IA2 to IB3 adenocarcinomas incorporating patient age, lymphovascular space invasion (LVSI) status, FIGO stage, and pattern of invasion according to the Silva system (traditionally a 3-tier system). Recently, a 2-tier/binary Silva pattern of invasion system has been proposed whereby adenocarcinomas are classified into low-risk (pattern A/pattern B without LVSI) and high-risk (pattern B with LVSI/pattern C) categories. Our cohort comprised 792 patients with HPV-associated EAC. Multivariate analysis showed that a binary Silva pattern of invasion classification was associated with recurrence-free and disease-specific survival (P < 0.05) whereas FIGO 2018 stage I substages were not. Evaluation of the current 3-tiered system showed that disease-specific survival for those patients with pattern B tumors did not significantly differ from that for those patients with pattern C tumors, in contrast to that for those patients with pattern A tumors. These findings underscore the need for prospective studies to further investigate the prognostic significance of stage I HPV-associated EAC substaging and the inclusion of the binary Silva pattern of invasion classification (which includes LVSI status) as a component of treatment recommendations. Copyright © 2024 by the International Society of Gynecological Pathologists.
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    MILACC study: could undetected lymph node micrometastases have impacted recurrence rate in the LACC trial?
    (BMJ Publishing Group, 2023) Nitecki, R; Ramirez, PT; Dundr, P; Nemejcova, K; Ribeiro, R; Vieira-Gomes, MT; Schmidt, RL; Bedoya, L; Isla, DO; Pareja, R; Rendón-Pereira, GJ; Lopez, A; Kushner, D; Cibula, D
    Objective The etiology of inferior oncologic outcomes associated with minimally invasive surgery for early-stage cervical cancer remains unknown. Manipulation of lymph nodes with previously unrecognized low-volume disease might explain this finding. We re-analyzed lymph nodes by pathologic ultrastaging in node-negative patients who recurred in the LACC (Laparoscopic Approach to Cervical Cancer) trial. Methods Included patients were drawn from the LACC trial database, had negative lymph nodes on routine pathologic evaluation, and recurred to the abdomen and/or pelvis. Patients without recurrence or without available lymph node tissue were excluded. Paraffin tissue blocks and slides from all lymph nodes removed by lymphadenectomy were re-analyzed per standard ultrastaging protocol aimed at the detection of micrometastases (>0.2 mm and ≤2 mm) and isolated tumor cells (clusters up to 0.2 mm or <200 cells). Results The study included 20 patients with median age of 42 (range 30-68) years. Most patients were randomized to minimally invasive surgery (90%), had squamous cell carcinoma (65%), FIGO 2009 stage 1B1 (95%), grade 2 (60%) disease, had no adjuvant treatment (75%), and had a single site of recurrence (55%), most commonly at the vaginal cuff (45%). Only one patient had pelvic sidewall recurrence in the absence of other disease sites. The median number of lymph nodes analyzed per patient was 18.5 (range 4-32) for a total of 412 lymph nodes. A total of 621 series and 1242 slides were reviewed centrally by the ultrastaging protocol. No metastatic disease of any size was found in any lymph node. Conclusions There were no lymph node low-volume metastases among patients with initially negative lymph nodes who recurred in the LACC trial. Therefore, it is unlikely that manipulation of lymph nodes containing clinically undetected metastases is the underlying cause of the higher local recurrence risk in the minimally invasive arm of the LACC trial.