Browsing by Author "Bravo-Taxa, M"

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Carcinoma coloide pancreático y tumor del estroma gastrointestinal del estómago sincrónicos: reporte de caso y revisión de la literatura
(Ediciones Doyma, S.L., 2022) Bravo-Taxa, M; Luque Vásquez-Vásquez, C; Guerrero-Quiroga, M; Taxa-Rojas, L
Colloid carcinoma (CC) is a rare histological type of adenocarcinoma of the pancreatic duct and is characterized by the presence of large lakes of extracellular mucin containing neoplastic cells. Its 5 year prognosis is more favourable than that of ductal, tubular or not otherwise specified (NOS) adenocarcinomas. We present the case of a 74-year-old woman with a thin walled, multicystic lesion in the tail of the pancreas, radiologically suggestive of a serous cystadenoma as opposed to a mucinous neoplasm. Surgery revealed a 10 x 6 cm lesion invading the splenic hilum and transverse mesocolon. Two nodes on the wall of the gastric fundus were also removed. Histopathology showed the pancreatic tumour to be a colloid carcinoma with a synchronous gastrointestinal stromal tumour of the gastric fundus.
Carcinoma hepatocelular ectópico: reporte de caso y revisión de la literatura
(Ediciones Doyma, S.L., 2022) Bravo-Taxa, M; Luque-Vásquez-Vásquez, C; Ruiz-Figueroa E; Taxa-Rojas, L
Ectopic liver (EL) is a rare developmental anomaly caused by the migration of hepatic cells to other locations during embryogenesis. Its incidence is thought to be between 0.24 and 0.47% and can occur in various sites, although the gall bladder is the most frequent. Approximately 100 cases of EL have been published, of which 28 developed hepatocellular carcinoma, whilst the orthotopic liver was unaffected. All cases are reported in Asian and Caucasian patients. We report the case of a 42-year-old patient with a solid lesion measuring 17×12×12 cm apparently arising from the posterior wall of the stomach, displacing various organs and suggestive of a gastrointestinal stromal tumour (GIST). The liver, biliary tract and other structures were unremarkable. Histopathology revealed a diagnosis of hepatocellular carcinoma in ectopic liver tissue.
Enfermedad de Paget extramamario primario de vulva concurrente con Lesión intraepitelial escamosa vulvar: reporte de caso
(Ediciones Doyma, S.L., 2023) Bravo-Taxa, M; Taxa-Rojas, L
Extramammary Paget's disease and intraepithelial vulvar neoplasia are common lesions in the vulva. However, their simultaneous occurrence is extremely rare. We present the case of a 77 year-old woman who presented with a 16 month history of pruritus and a rash in the vulvar region with gradually increasing bleeding. She underwent a right hemivulvectomy and a left simple vulvectomy. The histopathology revealed a coexistence of both Paget's disease and high grade intraepithelial vulvar neoplasia.
Hamartoma lipomatoso pancreático: Reporte de caso y revisión de la literatura
(Sociedad de Gastroenterología del Perú, 2023) Bravo-Taxa, M; Berrospi-Espinoza, F; Taxa-Rojas, L
Pancreatic hamartomas (PH) are extremely unusual non-neoplastic tumor-like lesions and accounts for <1% of all hamartomas. Moreover, there is a distinct variant of PH denominated Pancreatic lipomatous hamartoma (PLH), that is even rarer, with only 5 cases, including the present case, reported in the literature. PLH lacks well-defined features and clinically can be mistaken with other lipomatous lesions of the pancreas, including lipoma, pancreatic lipomatosis, PEComa, liposarcoma, and malignant tumors with lipomatous components. Here, we describe a case of PLH in a 70-year-old male with abdominal pain and a lesion, which was preoperatively diagnosed as a pancreatic no functional low-grade neuroendocrine tumor, and subsequent underwent a laparoscopic enucleation of the tumor. The postoperative pathology and immunohistochemical analyses confirmed the diagnosis of PLH.
Intestinal obstruction due to small intestinal metastasis from primary Merkel cell carcinoma of the gluteal region
(ecancer Global Foundation, 2022) Olivos-Gonzales, JF; Apumayta-Requena, E; Guevara-Jabiles, A; Bravo-Taxa, M
Merkel cell carcinoma (MCC) is a rare neoplasm of unknown multifactorial origin first described in 1972. It occurs most often in older Caucasian males and is typically associated with sun-exposed areas of skin. However, cases have also been reported in other areas, such as the trunk and the gluteal region. Metastatic disease will occur in up to one-third of cases at onset or during the course of the disease, including metastases to the abdominal organs. We present the case of a 53-year-old male with a history of primary MCC of the right buttock and local resection surgery. Eighteen months later, he presented with a small bowel obstruction and had an emergency segmental bowel resection. Pathology examination with immunohistochemistry concluded that findings were consistent with metastatic MCC. © 2022 ecancer Global Foundation. All rights reserved.
Ocho neoplasias primarias metacrónicas en paciente mujer adulta mayor
(Permanyer Publications, 2022) Purizaca-Rosillo, N; Aguilar-Villena, L; Bravo-Taxa, M; Sullcahuaman-Allende,Y; Rodríguez-Espinoza, M; Falla-Jiménez, M
Multiple primary neoplasms (MPN) are defined as 2 or more primary malignant tumors of different origin in the same individual. The cause of MPN has not been identified in all cases, however, it may be due to environmental factors, lifestyles and/or genetic factors. We present the case of a patient who has had eight neoplasms (five malignant and three benign) that have been successfully treated and who is currently undergoinf controls, with no evidence of disease recurrence or any other de novo neoplasm.
Primary Sclerosing Epithelioid Fibrosarcoma of the Kidney: A Case Report and Review of the Literature
(Wolters Kluwer Health, 2022) Bravo-Taxa, M; Garatea-Grau, R; Nuñez-Romero, U; Huanca-Amesquita, L
Sclerosing epithelioid fibrosarcoma (SEF) is a rare fibrosarcoma variant that features rounded carcinoma-like epithelioid cells arranged into compact nests, cords, and single-cell patterns within a highly sclerotic stroma and has a consistent translocation (EWSR1-CREB3L1/2). To our knowledge, there are 110 cases of pure SEF reported, to date, with 15 occurring at intra-abdominal sites. Primary SEF of the kidney is exceptionally rare. We present a case of SEF that arose in the kidney. Histological examination revealed densely hyalinized epithelioid tumor suggestive of SEF. The diffuse immunohistochemical staining of MUC4 by neoplastic cells and the presence of EWSR1 gene rearrangement by fluorescence in situ hybridization analysis confirmed the histological diagnosis.
Tumor neuroectodérmico maligno del tracto gastrointestinal: Reporte de 2 casos y revisión de la literatura
(Ediciones Doyma, S.L., 2022) Bravo-Taxa, M; Huanca-Amesquita, L
Malignant gastrointestinal neuroectodermal tumour (GNET) is an extremely rare neoplasm first described by Zambrano in 2003 as clear cell sarcoma like tumor of the gastrointestinal tract. In contrast to clear cell sarcoma, it has giant osteoclast cells and shows diffuse and intense positivity for S-100 with no immunohistochemical or ultrastructural melanocyte differentiation. We present the first cases of GNET reported in South America, occurring in Peru. Two cases of GNET, one in a female and one in a male, both between 60 and 70 years of age, were referred to our hospital for reevaluation. One underwent further treatment in our centre, but with an unfavourable evolution. Pathologists should be aware of the diagnostic criteria for GNET in order to avoid misdiagnosis due to confusion with other non-epithelial gastrointestinal neoplasms.
Valoración inicial de la tinción de Gissell, un nuevo método histopatológico en la identificación del Helicobacter pylori
(Ediciones Doyma, S.L., 2023) Ramirez-Ubillus, GC; Bravo-Taxa, M; Cruz-Baca, R; Neira-Montoya, R; Sedano-Gelvet, E
Introduction and Objectives: The histopathological identification of Helicobacter pylori using the routine method (haematoxylin–eosin) is not only very difficult but also has low sensitivity. Giemsa staining is often used in addition, but different protocols do not produce homogeneous results. Furthermore, the Gold Standard recommended by the European Helicobacter Pylori Study Group has been applied in very few studies, thus resulting in uncertain outcomes. Therefore, a new staining method is required to overcome these limitations. The aim of this study was to evaluate the diagnostic capacity and inter-observer agreement of “Gissell's stain”. Material and Methods: A cross-sectional study evaluated 99 gastric paraffin blocks from a private laboratory. Three sections were prepared from each block, and haematoxylin–eosin (HE), Giemsa and “Gissell's stain” methods were applied. The kappa statistics, sensitivity, specificity, and predictive values were calculated. Results: “Gissell's stain” obtained the highest inter-observer agreement (kappa = 0.87) compared to the other two methods (HE, kappa = 0.51; Giemsa, kappa = 0.83). It also obtained the best sensitivity and negative predictive value (97.1% and 98.3%, respectively) compared with the other two methods (HE: 68.6% and 85.1%, respectively; Giemsa: 88.6% and 93.9%, respectively). Conclusions: Given its unique characteristics (fast, cheap, accessible, and easy to use), in addition to its statistical reliability, “Gissell's stain” has great potential for routine use in the identification of H. pylori. © 2023 Sociedad Española de Anatomía Patológica