Browsing by Author "Appel, TM"

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    Update on the epidemiology of carbapenemases in Latin America and the Caribbean
    (Taylor and Francis Ltd., 2021) García-Betancur, JC; Appel, TM; Esparza, G; Gales, AC; Levy-Hara, G; Cornistein, W; Vega, S; Nuñez, D; Cuellar, L; Bavestrello, A; Castañeda-Méndez, F; Villalobos-Vindas, JM; Villegas, MV
    Introduction: Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam antibiotics, including carbapenems. Carbapenemase production in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp., with and without the co-expression of other β-lactamases is a serious public health threat. Carbapenemases belong to three main classes according to the Ambler classification: class A, class B, and class D. Areas covered: Carbapenemase-bearing pathogens are endemic in Latin America. In this review, we update the status of carbapenemases in Latin America and the Caribbean.Expert opinion: Understanding the current epidemiology of carbapenemases in Latin America and the Caribbean is of critical importance to improve infection control policies limiting the dissemination of multi-drug-resistant pathogens and in implementing appropriate antimicrobial therapy.