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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14703/47

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Browsing Artículos originales by Author "Abdul-Mumin, A"

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    Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study
    (BMJ Publishing Group, 2022) Abdelhafeez, H; Wilson, S; Nagras, S; Sheth, M; Dominic, C; Gandhi, S; Parwani, D; Raj, R; Munezero, D; Dutta, R; Roseline, NM; McClafferty, K; Nazari, A; Sriram, S; Pillarisetti, S; Nweze, KD; Ashwinee, A; Kalra, G; Patil, P; Nathani, P; Bhullar, KK; Elhadi, M; Khan, M; Rahim, N; Madhusudanan, S; Erhabor, J; Shirke, M; Mughal, A; Au, D; Salehi, M; Royyuru, S; Ahmed, M; Hussain, SNF; Robinson, D; Casey, A; Khan, M; Dukundane, A; Festus, K; Govind, V; Pancharatnam, R; Ochieng, L; Taylor, EH; Nautiyal, H; De Andres Crespo, M; Charuvila, S; Valetopoulou, A; Ravi, K; Jalloh, F; Badwi, N; Shah, S; Rajpal, R; Rana, M; Qadir, MA; Uwiringiyimana, E; Fanelli, MCA; Gomes, GMA; Buarque, IL; Guerini IS; Alfurais S; Gamal, M; Hijazi, Y; Tailakh, S; Al-Naggar, H; Douba, Z; Elejla, S; Eldaly, A; Sharashi, E; Mansour, A; Elyan, T; Zazo, A; Bonna, M; Alalami, H; Emam, RY; Alser, M; Abou Chaar, MK; Mazingi, D; Zuberi, HK; Ghosh, DN; Peters NJ; Davies L; Bwala KJ; Umar, AM; Aremu, A; Suleiman, DE; Aliyu, T; Gomes, P; Peter, N; Padilha, MAC; De Oliveira, EP; De Carvalho, LG; Diz, FL; El Kassas, M; Eldaly, U; Tawheed, A; Abdelwahab, M; Yassaad, OM; Hajar, B; Abdessamad EO; Yasser A; Laila H; Yahya, FS; Al-Agele, Y; Gallardo, MTP; Vásquez, JEM; León, JLG; Calvagna, V; Galea, N; Axiaq, A; Schuelke, MR; Kloeber, JA; Owen, RL; Roth, AS; Yang, C; Barnett, JH; Jay, LP; Wyatt, KD; Galardy, PJ; Vojcek A; Alrahawy MMA; Ragab SM; Allam, AR; Hager, EI; Azzam, A; Ayman, A; Cerit, KK; Daǧçinar, A; Umuroǧlu, T; Saraçoǧlu, A; Sakar, M; Kivrak, C; Çakmak, G; Sallam, I; Amira, G; Sherief, M; Sherif, A; De Oliveira Coelho, S; Ikeda A; Portela L; Garrigo MM; De Carvalho RV; Lobo, F; Ferman, SE; Da Silva, FF; Elhassan, MMA; Elhaj, NOY; Hamid, HKS; Ameh, EA; Nwatah, VE; Oyesakin, AB; Osuigwe, AN; Ekwunife, OH; Nri-Ezedi, CA; Umeh, EO; Bell, N; Ogundele, IO; Adekanmbi, AF; Fatungase, OM; Obafemi, O; Al-Furais, S; Hemlae, H; Nay, S; Mathew, J; Jeffri, RM; De Campos Vieira Abib, S; De Moraes Costa Carlesse, FA; De Souza, FKM; Lapolla, P; Mingoli, A; Cozzi, D; Testi, AM; Musiu, P; Sapienza, P; Brachini, G; Zambon, M; Meneghini, S; Cicerchia, P; Cirillo B; Taha, AO; Nesrine, A; Souad B; Malika, M; Belkacem, B; Meelad, A; Alrashed, HS; Haider, F; Al Fayez, FN; Rahim, F; Abdul-Mumin, A; Fuseini, HY; Kwarteng, PG; Abdulai, AB; Kunfah, SMP; Bonsaana, GB; Ajinkpang, S; Der, EM; Abantanga, FA; Kpiniong, MJ; Hattor KA; Bimpong, KA; Elbahnasawy, M; Abdelsalam, S; Samir, A; Baertschiger, RM; Brar, A; Bvulani, B; Patel, A; Nuhu-Koko, A; Jibrin, B; Olalekan, AL; Lukong, CS; Ajayi, EI; Guillén, G; López, S; Molino, JA; Velasco, P; Elmandouh, O; Hamam O; Elmandouh, R; Ruzgar, NM; Levinson, R; Kala, S; Ullrich, S; Christison-Lagay, E; Mortada, AS; Ebada, MA; Cross, K; Hayes-Jordan, A; Dasgupta, R; Elshami, M
    Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs. Design A multicentre, international, collaborative cohort study. Setting 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020. Participants Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, Wilms' tumour, sarcoma, retinoblastoma, gliomas, medulloblastomas or neuroblastomas, in keeping with the WHO Global Initiative for Childhood Cancer. Main outcome measure All-cause mortality at 30 days and 90 days. Results 1660 patients were recruited. 219 children had changes to their treatment due to the pandemic. Patients in LMICs were primarily affected (n=182/219, 83.1%). Relative to patients with paediatric cancer in HICs, patients with paediatric cancer in LMICs had 12.1 (95% CI 2.93 to 50.3) and 7.9 (95% CI 3.2 to 19.7) times the odds of death at 30 days and 90 days, respectively, after presentation during the COVID-19 pandemic (p<0.001). After adjusting for confounders, patients with paediatric cancer in LMICs had 15.6 (95% CI 3.7 to 65.8) times the odds of death at 30 days (p<0.001). Conclusions The COVID-19 pandemic has affected paediatric oncology service provision. It has disproportionately affected patients in LMICs, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently. However, many patients with paediatric cancer continued to receive their normal standard of care. This speaks to the adaptability and resilience of healthcare systems and healthcare workers globally.
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    Publication
    Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
    (BMJ Publishing Group, 2022) Bandyopadhyay, S; Lakhoo, K; Abdelhafeez, H; Wilson, S; Nagras, S; Sheth, M; Gandhi, S; Parwani, D; Raj, R; Munezero, D; Dutta, R; Roseline, NM; McClafferty, K; Nazari, A; Sriram, S; Pillarisetti, S; Nweze, K-D; Ashwinee, A; Kalra, G; Patil, P; Nathani, P; Bhullar, KK; Elhadi, M; Khan, M; Rahim, N; Madhusudanan, S; Erhabor, J; Shirke, M; Mughal, A; Au, D; Salehi, M; Royyuru, S; Ahmed, M; Hussain, SNF; Robinson, D; Casey, A; Khan, M; Dukundane, A; Festus, K; Govind, V; Pancharatnam, R; Ochieng, L; Taylor, EH; Nautiyal, H; De Andres Crespo, M; Charuvila, S; Valetopoulou, A; Zuberi, HK; Bwala, KJ; Umar, AM; Aremu, A; Suleiman, DE; Aliyu, T; Saleem, A; Arshad, M; Turk, K; Altaf, S; Ogunsua, OO; Sholadoye, TT; Tolani, MA; Alfa, Y; Musa, KM; Irungu, EM; Kendirlioglu, BC; Hicdonmez, T; Adhnon, A; Rana, AN; Humad, H; Madasu, A; Azzam, AY; Azab, MA; Ghozy, S; Abbas, AS; Dobs, M; Ghamry, MAM; Alhendy, M; Moses, O; Taibat, IT; Jones, T; Ukoha, K; Goke, O; Ikechukwu, O; Okunlola, AI; Chitnis, M; Nauhaus, H; Erwee, D; Brown, R; Chylinska, A; Simpson, R; Gomes, P; Peter, N; Padilha, MAC; De Oliveira, EP; Junior De Carvalho, LG; Diz, FL; El Kassas, M; Eldaly, U; Tawheed, A; Abdelwahab, M; Yassaad, OM; Hajar, B; El Abdessamad, O; Yasser, A; Laila, H; Yahya, FS; Al-Agele, Y; Rahul, SK; Kumar, V; Chaubey, D; Gallardo, MTP; Vásquez, JEM; León, JLG; Yip, SS; Karagiannidis G; Kebudi, R; Buyukkapu, SB; Govindarajan, KK; Sambandan, K; Kayal, S; Karunanithi, G; Naredi, BK; Jindal, B; Lami, M; Byrne, MHV; Jasim, D; Ghattaura, H; Etchill, EW; Rhee, D; Cooper, S; Crow, K; Drucker, M; Murphy, M; Shou, B; Siegel, A; Kara, Y; Özdemir, GN; Elfiky, M; El Refaee, E; Massoud, JG; Ibrahim, AB; Ibrahim, RB; Za'Nouneh, FA; Baddourah, RM; Fahmawee, T; Al-Shraideh, A; Salman, G; Alameer, E; Ali, A-M; Yahia, G; Waleed, K; Ozair, A; Bajaj, A; Ojha, BK; Singh, KK; Anwar, A; Suresh, V; Chaar, MKA; Sultan, I; Ghandour, K; Al-Dabaibeh, S; Al-Basiti, A; Ababneh, H; El-Qurneh, O; Alalawi, Y; Al Ayed, A; Hanafy, E; Al Bolowi, N; Lobo, F; Ferman, SE; Da Silva Lima, FF; Elhassan, MMA; Elhaj, NOY; Hamid, HKS; Ameh, EA; Nwatah, VE; Oyesakin, AB; Osuigwe, AN; Ekwunife, OH; Nri-Ezedi, CA; Umeh, EO; Bell, N; Ogundele, IO; Adekanmbi, AF; Fatungase, OM; Obadaini, OO; Al-Furais, S; Hemlae, H; Nay, S; Mathew, J; Ismail, RMJ; De Campos Vieira, Abib S; De Moraes Costa, Carlesse FA; Fanelli, MCA; De Souza, FKM; Lapolla, P; Mingoli, A; Cozzi, D; Testi, AM; Musiu, P; Sapienza P; Brachini, G; Zambon, M; Meneghini, S; Cicerchia, P; Cirillo, B; Tripathi, M; Peters, NJ; Mohindra, S; Kumar, V; Patil, NR; Jain, R; Madan, R; Karthigeyan, M; Salunke, P; Nambi, G; Taha, AO; Wong, JHL; Johari, N; Shikha, A; Han, WSP; Ahmad, Z; Lim, YY; Idros, R; Yusof, NM; Jaisingh, gDN; Nesrine, A; Souad, B; Malika, M; Belkacem, B; Haider, F; Al Fayez, FN; Rahim, F; Kleinman, E; Ibelli, T; Hamilton, E; Fayngor, R; Najman, T; Karplus, G; Adam, E; Melamed, D; Paasche, C; Labib, A; Laghari, FA; Ghosh, D; Al Balushi, Z; Al-Rawas, AAS; Al Sharqi, A; Al Shabibi, AS; Al Bulushi, I; Alshahri, M; AlMirza, A; Al Hamadani, O; Al Sharqi, J; Al Shamsi, A; Dawud, B; Al Sibai, S; Abdul-Mumin, A; Fuseini, HY; Kwarteng, PG; Abdulai, AB; Kunfah, SMP; Bonsaana, GB; Ajinkpang, S; Der, EM; Abantanga, FA; Kpiniong,; MJ; Hattor, KA; Bimpong, KA; Elbahnasawy, M; Abdelsalam, S; Samir, A; Baertschiger, RM; Brar, A; Matei, AC; Zani, A; Samad, L; Nadeem, K; Khayyam, N; Imran, FA; Zia, N; Muhammad, S; Raza, MR; Khan, MR; Hamdan, A; Omran, A; Moussa, A; Gawrieh, B; Salloum, H; Ahmed, A; Mazloum, A; Abodest, A; Ali, N; Hraib, M; Khoury, V; Ajayi, EI; Guillén, G; López, S; Molino, JA; Velasco, P; Elmandouh, O; Hamam, O; Elmandouh, R; Ruzgar,NM; Levinson, R; Kala, S; Ullrich, S; Christison-Lagay, E; Mortada, AS; Ebada,MA; Solimam, ESA; Abualkher, K; Yousf, AME; Holail, MM; Almowafy, RM; Kacimi, SEO; Elhalaby, E; Alser, M; Saad, MM; Pio, L; Seitz, G; Lindbert, J; Tsoulfas, G; Galli-Tsinopoulou, A; Madhuri, V; Kishore, R; Adel, MG; Virgone, C; Pata, F; Gallo, G; Oumaima, O; Bentounsi, Z; Ghosh, DN; Saldana, L; Godzinsky, J; Ali, A; Janic, D; Jalloh, MB; Jacobsen, A; Chui, CH; Pineda, IF; Krauel, L; Olivos, M; Rahama, W; Elfatih, H; Vuille-Dit-Bille, RN; Isik, A; Cross, K; Hayes-Jordan A; Dasgupta, R; Elshami, M
    Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68)